Quantum Transpiler Optimization: On the Development, Implementation, and Use of a Quantum Research Testbed

Quantum computing research is at the cusp of a paradigm shift. As the complexity of quantum systems increases, so does the complexity of research procedures for creating and testing layers of the quantum software stack. However, the tools used to perform these tasks have not experienced the increase in capability required to effectively handle the development burdens involved. This case is made particularly clear in the context of IBM QX Transpiler optimization algorithms and functions. IBM QX systems use the Qiskit library to create, transform, and execute quantum circuits. As coherence times and hardware qubit counts increase and qubit topologies become more complex, so does orchestration of qubit mapping and qubit state movement across these topologies. The transpiler framework used to create and test improved algorithms has not kept pace. A testbed is proposed to provide abstractions to create and test transpiler routines. The development process is analyzed and implemented, from design principles through requirements analysis and verification testing. Additionally, limitations of existing transpiler algorithms are identified and initial results are provided that suggest more effective algorithms for qubit mapping and state movement

Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies

The assessment of antibody responses after immunization with radiation-attenuated, aseptic, purified, cryopreserved Plasmodium falciparum sporozoites (Sanaria PfSPZ Vaccine) has focused on IgG isotype antibodies. Here, we aimed to investigate if P. falciparum sporozoite binding and invasion-inhibitory IgM antibodies are induced following immunization of malaria-preexposed volunteers with PfSPZ Vaccine.; Using serum from volunteers immunized with PfSPZ, we measured vaccine-induced IgG and IgM antibodies to P. falciparum circumsporozoite protein (PfCSP) via ELISA. Function of this serum as well as IgM antibody fractions was measured via in vitro in an inhibition of sporozoite invasion assay. These IgM antibody fractions were also measured for binding to sporozoites by immunofluorescence assay and complement fixation on whole sporozoites.; We found that in addition to anti-PfCSP IgG, malaria-preexposed volunteers developed anti-PfCSP IgM antibodies after immunization with PfSPZ Vaccine and that these IgM antibodies inhibited P. falciparum sporozoite invasion of hepatocytes in vitro. These IgM plasma fractions also fixed complement to whole P. falciparum sporozoites.; This is the first finding that PfCSP and P. falciparum sporozoite-binding IgM antibodies are induced following immunization of PfSPZ Vaccine in malaria-preexposed individuals and that IgM antibodies can inhibit P. falciparum sporozoite invasion into hepatocytes in vitro and fix complement on sporozoites. These findings indicate that the immunological assessment of PfSPZ Vaccine-induced antibody responses could be more sensitive if they include parasite-specific IgM in addition to IgG antibodies.; NCT02132299